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Hyaluronic Acid

Hyaluronic Acid is a glycosaminoglycan that is naturally present in the body. It is, among other things, the predominant hydration ingredient thanks to its ability to retain up to 1000 times its weight in water, thus promoting better collagen and elastin fiber binding. Over time, its natural production decreases, resulting in the formation of lines and wrinkles. Also from the age of 25 a person’s scalp begins to slowly shrink and with age the muscles and facial fat gradually atrophy. This results in more pronounced sagging of the facial and neck area skin and the reversal of the triangle of youth.


Replenishing the lost hyaluronic acid can be done in many different ways. One of them is nutrition. Eating certain foods increases the production of hyaluronic acid in the body. These foods belong to the HASPS (HA synthesis-promoting substances) category and are fresh vegetables (especially peppers) and fruits, soy and chicken. In recent years, however, drinking hyaluronic acid in liquid form, pills and capsules has also been discovered.


There is also a wide range of cosmetic products on the market, such as hyaluronic acid facial and eye creams, serums and masks. The formula of these creams has been greatly improved over the years, enabling the hyaluronic acid molecule to be reduced in size and molecular weight so that it can easily be absorbed into the skin.


But nowadays there are many methods of aesthetic medicine that introduce hyaluronic acid into the skin. Mesotherapy is one of them. It is done by injecting hyaluronic acid into the face, neck, décolleté and hands, just below the surface of the skin. It provides deep hydration and gives the skin a healthy, glowing look for a limited period of time.


Finally, there is an effective method of filling wrinkles or restoring volume where there is greater loss, using different types of hyaluronic acid. The most common application points for this method are the cheekbones, the temples, the lower jaw line, the lips and the chin.

Hyaluronic acid treatment for the face, body and joints is a very simple and safe procedure performed by dermatologists, plastic surgeons and orthopedists. This method can hydrate the skin, fill wrinkles, lips or cheekbones, and also reduce cartilage friction in the joints, making you more bendy and agile.


Hyaluronic acid facial treatment improves elasticity and rejuvenates the skin, making it look youthful and fresh. It all starts by having a discussion with your doctor in order to decide together how to proceed. Once you have decided on the quality, quantity and application points of hyaluronic acid, an anaesthetic cream is applied to the points where the infusion will be applied, making the procedure virtually pain-free.  At this stage you leave the cream to be absorbed for 30-40 minutes and then start the hyaluronic acid injection treatment, which lasts for no more than 5-10 minutes and is done using small sterile needles or atraumatic cannulas.


After the treatment, the doctor usually massages the area to distribute the material evenly and achieve the desired result. This procedure should not be performed without a doctor. The effect of the treatment is immediate, although a review by the doctor is usually done after 10-15 days.


It is worth noting that this non-invasive method of aesthetics with hyaluronic acid is not permanent. It usually has a duration of 9-15 months, but this depends on severalfactors. An important role in the duration of the result is played by gender, age, muscle mobility at the points of application of the treatment, facial expressiveness, lifestyle and of course the hyaluronic acid product used.



  1. Nasopharyngeal – nasolabial grooves
  2. Upper lip (smoker’s wrinkles)
  3. Lip augmentation
  4. Lip contour
  5. Facial oval
  6. Cheekbones
  7. Black eye circles (tear trough)
  8. Wrinkles on cheeks, forehead, eyes, neck and mid-eye
  9. Acne scars
  10. Postoperative scars
  11. Liquid facelift (8-point lift).


The new generation hyaluronic acid now used in hydration and rejuvenation treatments is certified by European and American bodies, which guarantee that it is completely safe. If applied by medical specialists (dermatologists or plastic surgeons) with experience in injectable treatments, the result will be natural and beautiful without side effects.


Do not use in:

  1. Kidney failure
  2. Liver failure
  3. Pregnancy
  4. Breastfeeding
  5. Anticoagulation treatment
  6. History of thromboembolic events
  7. Severe autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, etc.


Side effects

  1. Allergic reaction. It occurs very rarely in the form of swelling and redness in the area of application of injectable hyaluronic acid, but is treated immediately with the help of corticosteroids (cortisone and hydrocortisone).
  2. Bruising or swelling: It may occur at the site where hyaluronic acid was applied.
  3. Infection: If hygiene rules are not followed, some inflammation and infection may occur, but it subsides with the use of antibiotics.
  4. Undesirable results: In case more hyaluronic acid is needed to achieve the desired result, then we simply repeat the treatment. But even if the effect is too enhanced, it is easily reversible. It simply requires y to administer  the hyaluronic acid antidote, hyaluronidase,by injection to the required areas.
  5. Vascular oedema: After hyaluronic acid injection, severe swelling due to vasodilation may occur. The result can be distressing and of particular concern to the patient. However, it is fully reversible with cortisone administration in 2-3 24 hour periods.
  6. Vascular embolism: It is possible to inject hyaluronic acid into a major facial blood vessel. When this occurs, ,especially if it occurs in the terminal branch of an artery, then it can lead to necrosis of the skin that is perfused by this artery. Blindness has been described when the infusion is applied in the angular artery of the face (which is responsible for the blood supply of 75% of the retina). These conditions are extremely rare but can cause permanent damage. For this reason, the person interested in hyaluronic injection should consult specific medical specialties (Plastic Surgeons and Dermatologists), as these physicians have the experience and excellent knowledge of facial anatomy.


In general, treatment with hyaluronic acid injections is personalized and its cost is calculated by the doctor after the first visit, during which it will be discussed exactly what the patient wants and which areas are to be treated. Your doctor, having developed a treatment plan according to their assessment and desired aesthetic result  on the basis of your facial features, will help you to apply hyaluronic acid to those areas of the face that are most in need, in order to obtain a perfect and at the same time natural result, highlighting the beautiful features of your face.

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